Hormonal alterations elicited by the scorpion venom of Scorpio maurus palmatus, in vivo study

Document Type : Original Article

Authors

1 Toxicology department, College of science , suez canal, university.

2 zoology department, Faculty of Science, Suez Canal University

3 College of Medicine, Suez Canal University

4 Forensic and Toxicology Department College of Medicine, Suez Canal University

Abstract

Scorpion mauruspalmatus belongs to the family scor-pionidae and is common in the Middle East, and Mediterranean and regions .Study aim: is to study the hormonal alteration elicited by Scorpion maurus palmatus. Preparation the of lethal dose (LD50) The estimated LD50 of S. m. palmatus pooled venom was 10 mg/Kg and ¼ LD50 was used for toxicological studies (hormonal alteration) of this scorpion venom. Study design: Male albino mice (20–25 g) were housed in polyethylene cages (5/cage). Adult mice were injected intraperitoneally with crude S. m.palmatus venoms (¼ LD50 2.5mg/kg,5animals/group).
Results: Testoerone increased at all timepoints except in 6 hour(timepoint). The T3&T4 level was increased at all different timepoints.. Regarding the blood cortisol level was increased at three locations. However, in Sahab location the cortisol level was increased at 2 and 6 hours. However, at 24 h the concentration of cortisol was equal between treated and control groups. In Rehab location the blood insulin level in treated group was less than the control one.In Rehab location the blood insulin level in treated group was less than the control one. Regarding Sahab location theinsulin concentration level was equal in
treated and control groups in both 2, and 6 h time points, and increased at 24 h. In both Alagramia and WMCD locations, the insulin level concentration was increased in both 2, and 24h time point.
Conclusion:
Our study showed the S. m. palmatus scorpion has been altered the hormones of the study, remarkably increased at different time points.

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